Shared Biosynthesis of the Saliniketals and Rifamycins inSalinispora arenicolais Controlled by thesare1259-Encoded Cytochrome P450
نویسندگان
چکیده
منابع مشابه
Biosynthesis, Encodes a Putative Cytochrome P450 Monooxygenase
Phytoalexins are low molecular weight antimicrobial compounds that are synthesized in response to pathogen attack. The phytoalexin camalexin, an indole derivative, is produced by Arabidopsis in response to infection with the bacterial pathogen Pseudomonas syringae. The phytoalexin deficient 3 ( pad3 ) mutation, which causes a defect in camalexin production, has no effect on resistance to P. syr...
متن کاملCYTOCHROME P450 RosC & RosD IN ROSAMICIN BIOSYNTHESIS
Title 1 Function of cytochrome P450 enzymes RosC and RosD in the 2 biosynthesis of rosamicin macrolide antibiotic produced by 3 Micromonospora rosaria 4 5 Running Title 6 CYTOCHROME P450 RosC & RosD IN ROSAMICIN BIOSYNTHESIS 7 8 Yohei Iizaka, Noriko Higashi, Masanari Ishida, Reina Oiwa, Yumi Ichikawa, 9 Moeka Takeda, Yojiro Anzai*, and Fumio Kato 10 11 Faculty of Pharmaceutical Sciences, Toho U...
متن کاملThe roles of cytochrome P450 and P-glycoprotein in the pharmacokinetics of florfenicol in chickens
The effects of three selective oral inhibitors, fluvoxamine (FLU), ketoconazole (KET), and verapamil (VER), on the pharmacokinetics (PK) of florfenicol (FFC) were investigated in chickens. The chickens were administered orally with saline solution (SAL), FLU (60 mg/kg), KET (25 mg/kg), or VER (9 mg/kg) for 7 consecutive days. Florfenicol was given to the chickens at a single dose of 30 mg/kg or...
متن کاملCytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase.
Cytochrome P450 (P450) 2S1 is one of the orphan P450s without a clear physiological function. Controversy has arisen as to whether it can interact with NADPH-P450 reductase and accept electrons. The reduction of 1,4-bis{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione (AQ4N) by P450 2S1 was confirmed, and the NADPH consumption rates were measured aerobically and anaerob...
متن کاملUse of P450 cytochrome inhibitors in studies of enokipodin biosynthesis
Enokipodins A, B, C, and D are antimicrobial sesquiterpenes isolated from the mycelial culture medium of Flammulina velutipes, an edible mushroom. The presence of a quaternary carbon stereocenter on the cyclopentane ring makes enokipodins A-D attractive synthetic targets. In this study, nine different cytochrome P450 inhibitors were used to trap the biosynthetic intermediates of highly oxygenat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2010
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja105891a